主要論文リスト

当社の研究開発に関する主な英語論文を紹介します（2015年～）。

素材・成分に関する論文

2024年	Taishi Yasukawa, Ryo Iwama, Yuriko Yamasaki, Naohisa Masuo, Yoichi Noda Yeast Rim11 kinase responds to glutathione-induced stress by regulating the transcription of phospholipid biosynthetic genes Molecular Biology of the Cell, 2024, 35(1), 8 Ayako Sakuma, Yumiko Kai, YoshimitsuYamasaki, TomoyaTanaka, Takanobu Sakurai Oral administration of cysteine peptides attenuates UV-B-induced skin erythema and pigmentation in humans Scientific Reports, 2024, 14: 22163. Yoshiaki Uchida, Farhana Ferdousi, Shinya Takahashi, Hiroko Isoda Comprehensive Transcriptome Profiling of Antioxidant Activities by Glutathione in Human HepG2 Cells Molecules 2024, 29(5), 1090. https://doi.org/10.3390/molecules29051090 Hisae Aoshima, Ruka Mizuno, Yuho Iwatsu, Shiori Onishi, Sayuri Hyodo, Rinta Ibuki, Hirokazu Kawagishi, Yasukazu Saitoh Inhibitory Effect of 2-Aza-8-oxohypoxanthine on Tyrosinase Activity and Melanin Production Cosmetics, 2024, 11(2), 43.
2023年	Yoshiko Nakagawa-Nagahama, Masaki Igarashi, Masaomi Miura, Kosuke Kashiwabara, Keisuke Yaku, Yuichiro Fukamizu, Toshiya Sato, Takanobu Sakurai, Takashi Nakagawa, Takashi Kadowaki, Toshimasa Yamauchi Blood levels of nicotinic acid correlate with hearing ability in healthy older men BMC Geriatrics, 2023, 23(1), 97 Yoshiaki Uchida, Tomomi Kaneda, Mio Ono, Masao Matsuoka, Utano Nakamura, Akiko Ishida, Yoshimitsu Yamasaki, Hiroki Takeo, Takanobu Sakurai The Effect of Cysteine Peptide Ingestion on Skin Brightness, a Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Human Clinical Trial Cosmetics, 2023, 10(3), 72
2022年	Masaki Igarashi, Yoshiko Nakagawa-Nagahama, Masaomi Miura, Kosuke Kashiwabara, Keisuke Yaku, Mika Sawada, Rie Sekine, Yuichiro Fukamizu, Toshiya Sato, Takanobu Sakurai, Jiro Sato, Kenji Ino, Naoto Kubota, Takashi Nakagawa, Takashi Kadowaki, Toshimasa Yamauchi Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men NPJ Aging, 2022 Keisuke Okabe, Keisuke Yaku, Yoshiaki Uchida, Yuichiro Fukamizu, Toshiya Sato, Takanobu Sakurai, Kazuyuki Tobe, Takashi Nakagawa Oral administration of nicotinamide mononucleotide is safe and efficiently increases blood NAD+ levels in healthy subjects Frontiers in Nutrition, 2022 Mijin Kim, Jaehoon Seol, Toshiya Sato, Yuichiro Fukamizu, Takanobu Sakurai, Tomohiro Okura Effect of 12-week intake of nicotinamide mononucleotide on sleep quality, fatigue, and physical performance in older Japanese adults: A randomized double-blind placebo-controlled study Nutrients, 2022, 14(4), 755. Yuichiro Fukamizu, Yoshiaki Uchida, Akari Shigekawa, Toshiya Sato, Hisayuki Kosaka, Takanobu Sakurai Safety evaluation of excessive β-Nicotinamide mononucleotide intake in healthy adult men and women: a randomized double-blind placebo-controlled parallel-group study Scientific Reports, 2022, 12(1), 14442 Hisae Aoshima, Shinobu Ito, Rinta Ibuki, Hirokazu Kawagishi Potential of Fairy Chemicals as Functional Cosmetic Ingredients: Effect of 2-aza-8-oxohypoxanthine (AOH) on skin lightness International Journal of Medicinal Mushrooms, 2022, 24 (9), 41-47. DOI: 10.1615/IntJMedMushrooms.2022044611
2021年	Atsushige Ashimori, Yasukazu Nakahata, Toshiya Sato, Yuichiro Fukamizu, Takaaki Matsui, Hikari Yoshitane, Yoshitaka Fukada, Kazuyuki Shinohara, Yasumasa Bessho Attenuated SIRT1 Activity Leads to PER2 Cytoplasmic Localization and Dampens the Amplitude of Bmal1 Promoter-Driven Circadian Oscillation Frontiers in Neuroscience, 2021, 15. Chie Kitahara, Takanobu Sakurai, Kaori Furuta, Tadayoshi Katsumata Inhibition of lipid digestion by β-glucanase-treated Candida utilis Food Science and Technology Research, 2021, 27(4), 615-626. Takanobu Sakurai, Yusuke Fukuda, Akari Shigekawa, Satomi Iwahashi, Chie Kitahara, Yasuhito Yokoi, Toshiyuki Kaneko, Tadayoshi Katsumata Suppressive Effect of Water-soluble Dietary Fiber from Candida utilis on Postprandial Blood Glucose Level - A Randomized, Double-blind, Placebo-controlled, Crossover Study - 薬理と治療, 2021, 49(11), 1903-1911. Hisae Aoshima, PhD, Masayuki Ito, Rinta Ibuki, PhD, Hirokazu Kawagishi, PhD. The potential of 2-aza-8-oxohypoxanthine as a cosmetic ingredient Cosmetics, Special Issue 'Aesthetic and Cosmetic Dermatology', 2021, 8(3), 60. https://doi.org/10.3390/cosmetics8030060 Hisae Aoshima, Takunori Matsumoto, Rinta Ibuki, Hirokazu Kawagishi Safety evaluation of 2-aza-8-oxohypoxanthine by in vitro skin sensitization and human tests Fundam. Toxicol. Sci., 2021, 8(4), 123-133. https://doi.org/10.2131/fts.8.123 Hisae Aoshima, PhD, Rinta Ibuki, PhD, Masayuki Ito, Hirokazu Kawagishi, PhD. Clinical evaluation of topical lotion containing 2-aza-8-oxohypoxanthine on skin barrier function against water loss Cosmetics, 2021, 8(3), 83. https://doi.org/10.3390/cosmetics8030083 Yasukazu Saitoh, Asuka Tanaka, Sayuri Hyodo Protective Effects of Polyvinylpyrrolidone-Wrapped Fullerene Against Nitric Oxide/Peroxynitrite-Induced Cellular Injury in Human Skin Keratinocytes J Nanosci Nanotechnol, 2021, 21(9):4579-85. doi: 10.1166/jnn.2021.19279.
2020年	Takanobu Sakurai, Yusuke Fukuda, Akari Shigekawa, Satomi Iwahashi, Chie Kitahara, Yasuhito Yokoi, Tadayoshi Katsumata Effects of water-soluble dietary fiber from Candida utilis on postprandial serum triglyceride and safety evaluation of long-term and excessive intake of the Candida utilis extract in healthy subjects — Randomized, double-blind, placebo-controlled, crossover and parallel group study — Japanese Pharmacology Therapeutics, 2020, 48(5), 811-826 Taiki Fujii, Yusuke Matsuyama, Keita Hirano, Akinori Mimura, Keishi Hara, Hideo Mori, Toshiaki Imura Characterization and Application of a Novel Elastase from Streptomyces sp. P-3 Food Science and Technology Research, 2020, 26(6), 771-778 Hisae Aoshima, Sayuri Hyodo, Rinta Ibuki, Jing Wu, Jae-Hoon Choi, Hirokazu Kawagishi Safety evaluation of 2-aza-8-oxohypoxanthine based on in vitro and human patch tests Fundamental Toxicological Science, 2020, 7 (5), 207-214. https://doi.org/10.2131/fts.7.207
2019年	Yui Okabe, Yutaka Inoue, Yusuke Kanda, Tadayoshi Katsumata Odor-active compounds contributing to the characteristic aroma of shrimp cooked whole, including shells and viscera European Food Research and Technology, 245(1), 233_241, 2019 Akihito Fujimoto, Keisuke Ito, Noriko Narushima, Takahisa Miyamoto Identification of lactic acid bacteria and yeasts, and characterization of food components of sourdoughs used in Japanese bakeries. Journal of Bioscience and Bioengineering, 2019, 127(5), 575-581
2018年	Akihito Fujimoto, Keisuke Ito, Madoka Itou, Noriko Narushima, Takayuki Ito, Akihisa Yamamoto, Satoru Hirayama, Soichi Furukawa, Yasushi Morinaga, Takahisa Miyamoto Microbial behavior and changes in food constituents during fermentation of Japanese sourdoughs with different rye and wheat starting materials. Journal of Bioscience and Bioengineering, 125(1), 97_104, 2018
2016年	Yutaka Inoue, Tadayoshi Katsumata, Hirohito Watanabe, Fumitaka Hayase Mechanisms of D-Amino Acid Formation During Maturation of Sweet Rice Wine (mirin) Food Science and Technology Research, 22 (5), 679_686, 2016 Yasukazu Saitoh, Hiroaki Ohta , Sayuri Hyodo Protective effects of polyvinylpyrrolidone-wrapped fullerene against intermittent ultraviolet-A irradiation-induced cell injury in HaCaT cells J Photochem Photobiol B, 2016, 163:22-9. doi: 10.1016/j.jphotobiol.2016.08.001. Epub 2016 Aug 2.

基盤技術に関する論文

2022年	Taishi Yasukawa, Arisa H. Oda, Takahiro Nakamura, Naohisa Masuo, Miki Tamura, Yuriko Yamasaki, Makoto Imura, Takatomi Yamada, Kunihiro Ohta TAQing2.0 for genome reorganization of asexual industrial yeasts by direct protein transfection Communications Biology, 2022, 5(1), 1-13.
2021年	Makoto Imura, Shinichi Etoh, Ryo Iwakiri, Kenji Okano, Kohsuke Honda Improvement of production yield of l-cysteine through in vitro metabolic pathway with thermophilic enzymes Journal of bioscience and bioengineering, 132(6), 585-591(2021).
2020年	Taiki Fujii, Kazuhiro Fukano, Keita Hirano, Akinori Mimura, Miyu Terauchi, Shinichi Eto, Akihiro Iida A New Serine Protease Family with Elastase Activity is Produced by Streptomyces Bacteria Microbiology, 2020, 166(3), 253-261 Makoto Imura, Katsuaki Nitta, Ryo Iwakiri, Fumio Matsuda, Hiroshi Shimizu, Eiichiro Fukusaki Comparison of metabolic profiles of yeasts based on the difference of the Crabtree positive and negative J. Biosci. Bioeng, 2020,129(1), 52-58
2019年	Yohei Hanatani, Makoto Imura, Hironori Taniguchi, Kenji Okano, Yoshihiro Toya, Ryo Iwakiri, Kohsuke Honda In vitro production of cysteine from glucose Appl. Microbiol. Biotechnol, 2019, 103, 8009–8019 Hironori Taniguchi, Makoto Imura, Kenji Okano, Kohsuke Honda Developing a single strain for in vitro salvage synthesis of NAD + at high temperatures and its potential for bioconversion Microbial Cell Factories, 2019, 18(1):75
2018年	Makoto Imura, Ryo Iwakiri, Takeshi Bamba, Eiichiro Fukusaki Metabolomics approach to reduce the Crabtree effect in continuous culture of Saccharomyces cerevisiae Journal of Bioscience and Bioengineering, 126, 183-188 (2018).
2015年	Mikiko Nakamura, Ayako Suzuki, Junko Akada, Tohru Yarimizu, Ryo Iwakiri, Hisashi Hoshida, Rinji Akada A novel terminator primer and enhancer regents for direct expression of PCR-amplified genes in mammalian cells Molecular Biotechnology, 57, 767-780 (2015).